Sometimes Windows marks the save folder as "Read-Only," or your antivirus blocks the game from creating files.
It is important to distinguish between and In-Mission Saves : How to solve save failed problem - Hitman: Blood Money hitman blood money save failed
If you are playing on Steam and the game refuses to save or even boot properly, a missing or misplaced steam.dll might be the culprit. Sometimes Windows marks the save folder as "Read-Only,"
Find the steam.dll file in your main Steam folder (e.g., C:\Program Files (x86)\Steam ). C:\Program Files (x86)\Steam ).