The GameCube version features slightly better character models but suffers from more compressed audio files compared to the PC or Xbox counterparts. The Simpsons: Hit & Run - PCGamingWiki PCGW
Dolphin has some of the best rendering hacks available. You can easily bump internal resolution up to 4K and inject community-made HD texture packs. simpsons hit and run online emulator extra quality
To achieve true extra quality, standalone software running directly on your operating system is required. The GameCube Route via Dolphin simpsons hit and run online emulator extra quality